Sandra Fehsenfeld

Université du Québec à Rimouski
Postdoctoral fellow candidate

Supervisor: Piero Calosi
Start: 2019-01-01
End: 2020-12-31


The role of hormones in crustacean acid-base homeostasis and regulation in a changing environment
With the anthropogenically induced rise in atmospheric CO2, resulting in elevated ocean pCO2 (hypercapnia) and a drop in ocean pH (ocean acidification), acid-base regulation will become increasingly important for marine animals to respond to their changing environment. Any resulting disturbance of physiological homeostasis needs to be detected, communicated, and adjusted to by each organism. Very little, however, is known about endocrine regulation (i.e. hormones, hormone receptors, sensors) of acid-base balance in invertebrates. My research as a NSERC-PDF will focus on (i) characterizing the role of hormones in acid-base and ammonia regulation in crustaceans, (ii) how their endocrine system might be affected by global change, and (iii) how life history influences the endocrine capacity to counteract environmental changes.


crustacea, ocean acidification, acid-base regulation, ammonia excretion, teleosts, gill, kidney


1- Section-specific expression of acid-base and ammonia transporters in the kidney tubules of the goldfish Carassius auratus and their responses to feeding
Fehsenfeld, Sandra, Chris M. Wood
2018 American Journal of Physiology-Renal Physiology

2- Effects of salinity on short-term waterborne zinc uptake, accumulation and sub-lethal toxicity in the green shore crab ( Carcinus maenas )
Niyogi, Som, Tamzin A. Blewett, Trevor Gallagher, Sandra Fehsenfeld, Chris M. Wood
2016 Aquatic Toxicology

3- The role of an ancestral hyperpolarization-activated cyclic nucleotide-gated K+ channel in branchial acid-base regulation in the green crab,Carcinus maenas
Fehsenfeld, Sandra, Dirk Weihrauch
2016 The Journal of Experimental Biology

4- Making sense of nickel accumulation and sub-lethal toxic effects in saline waters: Fate and effects of nickel in the green crab, Carcinus maenas
Blewett, Tamzin A., Chris N. Glover, Sandra Fehsenfeld, Michael J. Lawrence, Som Niyogi, Greg G. Goss, Chris M. Wood
2015 Aquatic Toxicology

5- Cutaneous nitrogen excretion in the African clawed frog Xenopus laevis: Effects of high environmental ammonia (HEA)
Cruz, Melissa J., Mary M. Sourial, Jason R. Treberg, Sandra Fehsenfeld, Aida Adlimoghaddam, Dirk Weihrauch
2013 Aquatic Toxicology

6- Differential acid–base regulation in various gills of the green crab Carcinus maenas: Effects of elevated environmental pCO2
Fehsenfeld, Sandra, Dirk Weihrauch
2013 Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

7- Effects of elevated seawater p CO2 on gene expression patterns in the gills of the green crab, Carcinus maenas
Fehsenfeld, Sandra, Rainer Kiko, Yasmin Appelhans, David W Towle, Martin Zimmer, Frank Melzner
2011 BMC Genomics

8- Effects of high environmental ammonia on branchial ammonia excretion rates and tissue Rh-protein mRNA expression levels in seawater acclimated Dungeness crab Metacarcinus magister
Martin, Michael, Sandra Fehsenfeld, Mary M. Sourial, Dirk Weihrauch
2011 Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

9- Mechanisms of acid–base regulation in seawater-acclimated green crabs (Carcinus maenas)
Fehsenfeld, S., D. Weihrauch
2016 Canadian Journal of Zoology