Alan Cohen

Assistant Professor,
Université de Sherbrooke

Département de médecine de famille
2500, boul. de l'Université, Sherbrooke (Québec) CANADA J1K 2R1
Tel: 819-820-6868 poste 12589
Fax: 819-820-6419
Institution page
Personal page

  • PhD Biology, University of Missouri-2007
  • BA Biology and Asian Studies, University of Michigan-1999

Dr.Cohen uses longitudinal epidemiological data to establish causal relationships between the mechanisms underlying aging and biomarkers. He applies similar methods to different species to understand how physiological regulatory networks operate at different time scales, and how to measure their impact on the evolution of physiology over time depending on environmental changes and selection pressure. In the long term, he hopes to generate a method for measuring biological age, which could be applied clinically.

QCBS students
Frédérik Dufour, Ph.D.
(Start: 2016)
Other (co-)supervisor: Pierre-Étienne Jacques, Université de Sherbrooke
Thesis title: Étude de la dérégulation des systèmes physiologiques dans le vieillissement ; Approche bio-informatique
Previous students (since 2009)
Patrick Bergeron, Postdoctoral fellow
(Start: 2013, End: 2014)
Other (co-)supervisor: Alain Vanasse, Université de Sherbrooke
Yasmine SERME, Ph.D.
(Start: 2013, End: 2016)
Other (co-)supervisor: Takser, Larissa
Thesis title: Exposition aux ignifuges bromés, perturbateurs thyroïdiens d’origine environnementale, et développement cérébral chez les enfants de la cohorte GESTE.
Vincent Morissette-Thomas, M.Sc.
(Start: 2013, End: 2015)
Other (co-)supervisor: Taoufik Bouezmarni, Université de Sherbrooke
Thesis title: Multivariate analysis of biomarkers to better characterize their impact on the aging process
Relevant QCBS research themes
52- The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations
Cohen A.A., Legault V., Fuellen G., Fülöp T., Fried L.P., Ferrucci L.
2017 Experimental Gerontology (Date Added: 2017-08-02)

51- Aging across the tree of life: The importance of a comparative perspective for the use of animal models in aging
Cohen A.A.
2017 Biochimica et Biophysica Acta - Molecular Basis of Disease (Date Added: 2017-07-28)

50- Initiating an antipsychotic drug treatment for schizophrenia: The situation in Quebec, Canada, from 1998 to 2006
Carrier J., Blais L., Cohen A., Courteau J., Roberge P., Larouche A., Grignon S., Fleury M., Lesage A., Demers M., Roy M., Delorme A., Vanasse A.
2017 Sante Mentale au Quebec (Date Added: 2017-07-22)

49- Deep biomarkers of aging are population-dependent
Cohen A., Morissette-Thomas V., Ferrucci L., Fried L.
2016 Aging (Date Added: 2017-02-14)

48- Deep biomarkers of aging are population-dependent
Cohen, A.A., Morissette-Thomas, V., Ferrucci, L., Fried, L.P.
2016 Aging (Date Added: 2016-11-23)

47- Comparative effectiveness and safety of antipsychotic drugs in schizophrenia treatment: a real-world observational study
Vanasse, A., Blais, L., Courteau, J., Cohen, A.A., Roberge, P., Larouche, A., Grignon, S., Fleury, M.-J., Lesage, A., Demers, M.-F., Roy, M.-A., Carrier, J.-D., Delorme, A.
2016 Acta Psychiatrica Scandinavica (Date Added: 2016-08-04)

46-Taxonomic diversity, complexity, and the evolution of senescence
Cohen, A.A
2016 The Evolution of Senescence in the Tree of Life ( Date Added: 2016-07-05)

45- Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE
Serme-Gbedo, Y.K., Abdelouahab, N., Pasquier, J.-C., Cohen, A.A., Takser, L.
2016 Environmental Health : a Global Access Science Source (Date Added: 2016-05-27)

44- Association between Floods and Acute Cardiovascular Diseases: A Population-Based Cohort Study Using a Geographic Information System Approach
Vanasse, A., Cohen, A., Courteau, J., Bergeron, P., Dault, R., Gosselin, P., Blais, C., Belanger, D., Rochette, L., Chebana, F.
2016 International Journal of Environmental Research and Public Health (Date Added: 2016-02-12)

43- Complex systems dynamics in aging: new evidence, continuing questions
Cohen, A.A.
2016 Biogerontology (Date Added: 2016-02-06)

41- Frailty, Inflammation and Immunosenescence
Fulop, T., McElhaney, J., Pawelec, G., Cohen, A.A., Morais, J.A., Dupuis, G., Baehl, S., Camous, X., Witkowski, J.M., Larbi, A.
2015 Interdisciplinary Topics in Gerontology and Geriatrics (Date Added: 2016-03-07)

40- Homeostatic dysregulation proceeds in parallel in multiple physiological systems
Li, Q., Wang, S., Milot, E., Bergeron, P., Ferrucci, L., Fried, L.P., Cohen, A.A.
2015 Aging Cell (Date Added: 2016-01-31)

39- Physiological Regulatory Networks: The Orchestra of Life?
Martin, L.B., Cohen, A.A.
2015 (Date Added: 2015-11-30)

38- A theoretical model of the evolution of actuarial senescence under environmental stress
Watson, H., Cohen, A.A., Isaksson, C.
2015 Experimental Gerontology (Date Added: 2015-11-23)

37- Evolution and the Biology of Aging
Cohen, A.A., Holmes, D.J.
2015 Reference Module in Biomedical Research (Date Added: 2015-11-16)

36- Detection of a novel, integrative aging process suggests complex physiological integration
Cohen, A.A., Milot, E., Li, Q., Bergeron, P., Poirier, R., Dusseault-Belanger, F., Fulop, T., Leroux, M., Legault, V., Metter, E.J., Fried, L.P., Ferrucci, L.
2015 PloS one (Date Added: 2015-09-29)

35- Neighbourhood immigration, health care utilization and outcomes in patients with diabetes living in the Montreal metropolitan area (Canada): a population health perspective
Vanasse, A., Courteau, J., Orzanco, M.G., Bergeron, P., Cohen, A.A., Niyonsenga, T.
2015 BMC Health Services Research (Date Added: 2015-09-25)

34- Environmental Factors Associated With Social Participation of Older Adults Living in Metropolitan, Urban, and Rural Areas: The NuAge Study
Levasseur, M., Cohen, A.A., Dubois, M.-F., Genereux, M., Richard, L., Therrien, F.-H., Payette, H.
2015 American Journal of Public Health (Date Added: 2015-08-10)

33-On the immunological theory of aging
Fülöp, T., J.M. Witkowski, G. Pawelec, A.A. Cohen, and A. Larbi
2014 Aging: Facts and Theories ( Date Added: 2016-07-05)

32- Inflamm-aging does not simply reflect increases in pro-inflammatory markers
Morrisette-Thomas, V., Cohen, A.A., Fulop, T., Riesco, E., Legault, V., Li, Q., Milot, E., Dusseault-Belanger, F., Ferrucci, L.
2014 Mechanisms of Ageing and Development (Date Added: 2016-07-05)

31- Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations
Milot, E., Morissette-Thomas, V., Li, Q., Fried, L.P., Ferrucci, L., Cohen, A.A.
2014 Mechanisms of Ageing and Development (Date Added: 2015-12-21)

30- Beta-blockers are associated with increased risk of first cardiovascular events in non-diabetic hypertensive elderly patients
Brouwers, F.M., Courteau, J., Cohen, A.A., Farand, P., Cloutier, L., Asghari, S., Vanasse, A.
2014 Pharmacoepidemiology and Drug Safety (Date Added: 2015-07-27)

29- Stress Responsive Biochemical Anabolic/Catabolic Ratio and Telomere Length in Older Adults
Vasunilashorn, Sarinnapha, Cohen, Alan A.
2014 Biodemography and Social Biology (Date Added: 2014-11-17)

28- Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
Cohen, Alan A., Milot, Emmanuel, Li, Qing, Legault, Véronique, Fried, Linda P., Ferrucci, Luigi
2014 Experimental Gerontology (Date Added: 2014-08-05)

27- Rapid behavioural gregarization in the desert locust, Schistocerca gregaria entails synchronous changes in both activity and attraction to conspecifics
Rogers, Stephen M., Cullen, Darron A., Anstey, Michael L., Burrows, Malcolm, Despland, Emma, Dodgson, Tim, Matheson, Tom, Ott, Swidbert R., Stettin, Katja, Sword, Gregory A., Simpson, Stephen J.
2014 Journal of Insect Physiology (Date Added: 2014-05-27)

26- A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation
Milot, E., Cohen, A.A., Vézina, F., Buehler, D.M., Matson, K.D., Piersma, T.
2014 Methods in Ecology and Evolution (Date Added: 2014-05-23)

25-Fragilité et maladies chroniques: Définitions, controverses et perspectives d'action
Fulop, T., A.A. Cohen, J. McElhaney, J. Morais, and A. Larbi
2013 La Fragilité des Personnes gées ( Date Added: 2016-07-05)

24-The importance of distinguishing mathematical and biological. Comment on Mate Choice and the Origin of Menopause plausibility.
Cohen, A.A., D.A. Levitis, and M. Burton-Chellew
2013 PLoS Computational Biology ( Date Added: 2016-07-05)

23- Circulating carotenoid levels are negatively associated with previous reproductive success in Florida Scrub-Jays (Aphelocoma coerulescens)
Cohen, A.A., Bowman, R., Boughton, R.K., Bridge, E., Heiss, R.S., Schoech, S.J., McGraw, K.J.
2013 Canadian Journal of Zoology (Date Added: 2014-05-23)

22- A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
Cohen, A.A., Milot, E., Yong, J., Seplaki, C.L., Fülöp, T., Bandeen-Roche, K., Fried, L.P.
2013 Mechanisms of Ageing and Development (Date Added: 2014-05-23)

21- Validating metabolic syndrome through principal component analysis in a medically diverse, realistic cohort
Dusseault-Belanger, F., Cohen, A.A., Hivert, M.-F., Courteau, J., Vanasse, A.
2013 Metabolic Syndrome and Related Disorders (Date Added: 2014-05-23)

20- Does elapsed time between first diagnosis of schizophrenia and migration between health territories vary by place of residence? A survival analysis approach
Ngamini Ngui, A., Cohen, A.A., Courteau, J., Lesage, A., Fleury, M.-J., Grégoire, J.-P., Moisan, J., Vanasse, A.
2013 Health and Place (Date Added: 2014-05-23)

19- Ecological immunology in a fluctuating environment: an integrative analysis of tree swallow nestling immune defense
Pigeon, Gabriel, Bélisle, Marc, Garant, Dany, Cohen, Alan A., Pelletier, Fanie
2013 Ecology and Evolution (Date Added: 2013-09-17)

18-Favoriser la participation sociale et la santé de la population vieillissante grâce aux enquêtes populationnelles et à la géomatique : un exemple d’une initiative méthodologique possible
Levasseur, M., A. Vanasse, J. Courteau, M. Généreux, A.A. Cohen, and Y. Kestens
2012 Médecine Sciences ( Date Added: 2016-07-05)

17- Modified metabolic syndrome criteria for identification of patients at risk of developing diabetes and coronary heart diseases: longitudinal assessment via electronic health records
Hivert, M.-F., Dusseault-Belanger, F., Cohen, A., Courteau, J., Vanasse, A.
2012 The Canadian Journal of Cardiology (Date Added: 2016-07-05)

15- Specialized cardiological care may be overutilized in urban areas of Québec
Cohen, A.A., Vanasse, A., Courteau, J.
2012 European Journal of Preventive Cardiology (Date Added: 2014-05-23)

14- Physiological regulatory networks: Ecological roles and evolutionary constraints
Cohen, A.A., Martin, L.B., Wingfield, J.C., McWilliams, S.R., Dunne, J.A.
2012 Trends in Ecology and Evolution (Date Added: 2014-05-23)

13- Circulating carotenoid concentrations are positively correlated with later clutch initiation in Florida Scrub-Jays (Aphelocoma coerulescens)
Heiss, R.S., Cohen, A.A., Bowman, R., Boughton, R.K., Bridge, E., McGraw, K.J., Schoech, S.J.
2011 Journal of Experimental Zoology Part A: Ecological Genetics and Physiology (Date Added: 2014-05-23)

12- The ecological significance of antioxidants and oxidative stress: A marriage between mechanistic and functional perspectives
McGraw, K.J., Cohen, A.A., Costantini, D., Hõrak, P.
2010 Functional Ecology (Date Added: 2014-05-23)

11- How to measure oxidative stress in an ecological context: Methodological and statistical issues
Hõrak, P., Cohen, A.
2010 Functional Ecology (Date Added: 2014-05-23)

10- Ecological, biomedical and epidemiological approaches to understanding oxidative balance and ageing: What they can teach each other
Cohen, A.A., De Magalhães, J.P., Gohil, K.
2010 Functional Ecology (Date Added: 2014-05-23)

9- The Summary Index of Malaria Surveillance (SIMS): A stable index of malaria within India
Cohen, A.A., Dhingra, N., Jotkar, R.M., Rodriguez, P.S., Sharma, V.P., Jha, P.
2010 Population Health Metrics (Date Added: 2014-05-23)

8- No consistent effects of prenatal or neonatal exposure to Spanish flu on late-life mortality in 24 developed countries
Cohen, A.A., Tillinghast, J., Canudas-Romo, V.
2010 Demographic Research (Date Added: 2014-05-23)

7- Adult and child malaria mortality in India: A nationally representative mortality survey
Dhingra, N., Jha, P., Sharma, V.P., Cohen, A.A., Jotkar, R.M., Rodriguez, P.S., Bassani, D.G., Suraweera, W., Laxminarayan, R., Peto, R.
2010 The Lancet (Date Added: 2014-05-23)

5- Complexity in relationships between antioxidants and individual life-history parameters in a seabird and a songbird
Cohen, A.A., Mauck, R.A., Wheelwright, N.T., Huntington, C.E., McGraw, K.J.
2009 Oikos (Date Added: 2014-05-23)

4- Serum antioxidant levels in wild birds vary in relation to diet, season, life history strategy, and species
Cohen, A.A., McGraw, K.J., Robinson, W.D.
2009 Oecologia (Date Added: 2014-05-23)

3- Interspecific associations between circulating antioxidant levels and life-history variation in birds
Cohen, A.A., McGraw, K.J., Wiersma, P., Williams, J.B., Robinson, W.D., Robinson, T.R., Brawn, J.D., Ricklefs, R.E.
2008 American Naturalist (Date Added: 2014-05-23)

2- Spectral mimicry: A method of synthesizing matching time series with different Fourier spectra
Cohen, J.E., Newman, C.M., Cohen, A.E., Petchey, O.L., Gonzalez, A.
1999 Circuits, Systems, and Signal Processing (Date Added: 2011-03-22)

1- A novel experimental apparatus to study the impact of white noise and 1/f noise on animal populations
Cohen, A.E., Gonzalez, A., Lawton, J.H., Petchey, O.L., Wildman, D., Cohen, J.E.
1998 Proceedings of the Royal Society B: Biological Sciences (Date Added: 2011-08-26)